The San Diego Padres (88-66) take on the Chicago White Sox (36-118), who will be trying to halt a three-game losing streak, ...

Manny Machado and the San Diego Padres square off against the Chicago White Sox and starter Chris Flexen on Saturday at 8:40 ...

Manny Machado’s San Diego Padres play the Chicago White Sox on Sept. 21 at 8:40 PM ET, and will see starting pitcher Chris ...

The Chicago White Sox staged a two-out rally in the 9th but fell to the San Diego Padres 3-2 in 10 on Friday. The Sox are ...

Lenyn Sosa hit a tying two-run homer with two outs in the ninth inning, but the Chicago White Sox lost their 118th game when ...

The Chicago White Sox (36-117) kick off a three-game series on Saturday against the San Diego Padres (87-66). The matchup ...

Preview the Sept. 21 matchup between the San Diego Padres and Chicago White Sox with odds over/under, game spread, betting ...

Fernando Tatis Jr.'s run-scoring hit leading off the 10th lifted the Padres to a 3-2 victory over the White Sox Friday.

As the defeats continue to mount, the White Sox have joined the discussion of the most infamous baseball teams of all time.

The Cubs are closing out the season with 10 of their final 13 games at Wrigley Field, while the White Sox have a tall task ...

Preview the Padres vs. White Sox game today, with score predictions, stats, starting pitchers and game information.

What to look for from the top San Diego Padres and Chicago White Sox players and how to watch the game as they face off on ...