How to measure and evaluate binding affinities | eLife
WEBAug 6, 2020 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models. Given the advances in high-throughput technologies and the projected increase in the availability of binding data, we found it especially timely to evaluate the current standards for ...
For Authors: A simpler way to submit to eLife
WEBMar 11, 2019 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Reviewed Preprints - eLife
WEB4 days ago · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Sodium taurocholate cotransporting polypeptide is a functional …
WEBNov 13, 2012 · Liver diseases related to the human hepatitis B virus (HBV) kill about 1 million people every year, and more than 350 million people around the world are infected with the virus. Some 15 million of these people are also infected with the hepatitis D virus (HDV), which is a satellite virus of HBV, and this places them at an even higher risk of liver diseases, including cancer.
Ten simple rules for the computational modeling of behavioral data
WEBNov 26, 2019 · The goal of computational modeling in behavioral science is to use precise mathematical models to make better sense of behavioral data. The behavioral data most often come in the form of choices, but can also be reaction times, eye movements, or other easily observable behaviors, and even neural data. The models come in the form of mathematical ...
Science Forum: SARS-CoV-2 (COVID-19) by the numbers - eLife
WEBMar 31, 2020 · Abstract. The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the …
Lysosome activity is modulated by multiple longevity pathways …
WEBJun 2, 2020 · Lysosomes are dynamic organelles responsible for macromolecule degradation and catabolite recycling. Lysosomes also serve as a signaling hub to integrate nutritional, energy and growth factor information and coordinate cellular responses through key regulatory modules docked on the lysosomal surface (Lawrence and Zoncu, 2019).By acting as centers of degradation, recycling and signaling ...
DunedinPACE, a DNA methylation biomarker of the pace of aging
WEBJan 14, 2022 · The refined DNA-methylation dataset used for machine-learning improves reliability of measurement. We name the novel algorithm DunedinPACE, for Dunedin (P)ace of (A)ging (C)alculated from the (E)pigenome. As a new DNA methylation measure of biological aging, DunedinPACE joins a well-established battery of DNA methylation measures known as ...
Independent regulation of Z-lines and M-lines during sarcomere
WEBNov 3, 2023 · This manuscript describes a useful tool for quantitative assessment of sarcomere structures in healthy and perturbed cardiomyocytes grown in vitro. The work is solid, and the methods, data and analyses broadly support the claims with only minor weaknesses.The tool will be relevant to biologists working on and interested in obtaining quantitative information on sarcomere structure, function and ...
eLife Lens
WEBeLife Lens provides a novel way of looking at content on the web. It is designed to make life easier for researchers, reviewers, authors and readers.